Publications

2018

 

Hou JQ, Kovacs MS, Dhanvantari S, Luyt LG: Development of Candidates for PET Imaging of Ghrelin Receptor in Disease: Design, Synthesis and Evaluation of Fluorine-bearing Quinazolinone Derivatives. J Med Chem 2018.

DOI: 10.1021/acs.jmedchem.7b01754

 

 

 

 

Abstract Image

2017

 

Simpson EJ, Gobbo P, Bononi FC, Murrell E, Workentin MS, Luyt LG: Bombesin-functionalized water-soluble gold nanoparticles for targeting prostate cancer. Journal of Interdisciplinary Nanomedicine, 2(4):174-187, 2017.

DOI: 10.1002/jin2.33

 

Cho, C-F; Yu, L; Nsiama, TK; Amadei, GA; Shukla, S; Steinmetz, NF; Luyt, LG; Lewis, JD. Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neoangiogenesis. Nanoscale 9, 12096-12109, 2017.

DOI: 10.1039/c7nr02558k

Graphical abstract: Viral nanoparticles decorated with novel EGFL7 ligands enable intravital imaging of tumor neovasculature

Sun, N; Wang, C; Xu, M-H; Lu, Y-J; Zheng, Y-Y; Yan, Y; Guo, X-L; Hou, J; Zhang, K; Luyt, LG; Wong, W-L; Chow, C-F. The Interaction of a Structural Flexible Small Molecule with Nucleic Acid Structures: Investigation of the Origin of Fluorescence Signal Discrimination in Sensing and the Utilization in Live Cell Imaging. Sensors and Actuators B: Chemical 250, 543-551, 2017.

DOI: 10.1016/j.snb.2017.05.018

https://ars.els-cdn.com/content/image/1-s2.0-S0925400517308316-fx1_lrg.jpg

Charron, C. L.; Hou, J.; McFarland, M. S.; Dhanvantari, S.; Kovacs, M. S.; Luyt, L. G., Structure-Activity Study of Ghrelin(1-8) Resulting in High Affinity Fluorine-Bearing Ligands for the Ghrelin Receptor. J Med Chem, 60 (17), 7256-7266, 2017.

DOI: 10.1021/acs.jmedchem.7b00164

Abstract Image

Bahrami, SB; Tolg, C; Peart, T; Symonette, C; Veiseh, M; Umoh, JU; Holdsworth, DW; McCarthy, JB; Luyt, LG; Bissell, MJ; Yazdani, A; Turley, EA. Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis. Integrative Biology 9, 223-237, 2017.
DOI: 10.1039/c7ib00002b

Barbon, SM; Novoa, S; Bender, D; Groom, H; Luyt, LG; Gilroy, JB. Copper-assisted azide-alkyne cycloaddition chemistry as a tool for the production of emissive boron difluoride 3-cyanoformazanates. Org. Chem. Frontiers 4(2), 178-190, 2017.
DOI: 10.1039/c6qo00640j

 


2016

 

Hou, J; Charron, CL; Fowkes, MM; Luyt, LG. Bridging Computational Modeling with Amino Acid Replacements to Investigate GHS-R1a-Peptidomimetic Recognition. Eur. J. Med. Chem., 822-833, 2016.
DOI: 10.1016/j.ejmech.2016.07.078

 

Cho, CF; Lee, K; Speranza, MC; Bononi, FC; Viapiano, MS; Luyt, LG; Weissleder, R; Chiocca, EA; Lee, H; Lawler, SE. Design of a Microfluidic Chip for Magnetic-Activated Sorting of One Bead-One-Compound Libraries. ACS Combi. Sci. 18(6), 271-278, 2016.
DOI: 10.1021/acscombsci.5b00180

 

Charron, CL; Hickey, JL; Cruickshank, D; Nsiama, T; Turnbull, W; Luyt, LG. Molecular Imaging Probes Derived from Natural Peptides. Natural Product Reports 33, 761-800, 2016.
DOI: 10.1039/C5NP00083A

Gavin, C.T., Ali, S.N., Tailly, T., Olvera-Posada, D; Alenezi, H; Power, NE; Hou, J-Q; St. Amant, A; Luyt, LG; Wood, S; Wu, C; Razvi, H; Leong, HS. Novel Methods of Determining Urinary Calculi Composition: Petrographic Thin Sectioning of Calculi and Nanoscale Flow Cytometry Urinalysis. Scientific Reports, 19328, 2016.
DOI: 10.1038/srep19328

 

 

Lu, Y-J; Deng, Q; Hou, J-Q; Hu, D-P; Wang, Z-Y; Zhang, K; Luyt, LG; Wong, W-L; Chow, C-F. Molecular Engineering of Thiazole Orange Dye: Change of Fluorescent Signaling from Universal to Specific upon Binding with Nucleic Acids in Bioassay. ACS Chemical Biology, 11 (4), pp 1019–1029, 2016.
DOI: 10.1021/acschembio.5b00987

2015

 

Esguerra, KVN; Tolg, C; Akentieva, N; Price, M; Cho, C-F; Lewis, JD; McCarthy, JB; Turley, EA; Luyt, LG. Identification, Design and Synthesis of Tubulin-Derived Peptides as Novel Hyaluronan Mimetic Ligands for the Receptor for Hyaluronan-Mediated Motility (RHAMM/HMMR). Integrative Biology 7, 1547-1560, 2015.
DOI: 10.1039/C5IB00222B

 

Maar, RR; Barbon, SM; Sharma, N; Groom, H; Luyt, LG; Gilroy, JB. Evaluation of Anisole-Substituted Boron Difluoride Formazanate Complexes for Fluorescence Cell Imaging. Chemistry – A European Journal 21(44), 15589–15599, 2015.
DOI 10.1002/chem.201502821

Hou J-Q; Zan L-P; Chen S-B; Gu L-Q; Tan J-H; Luyt LG; Huang Z-S. Identification of selective G-quadruplex binder by a multistep virtual screening approach. Chem. Comm. 51, 198-201, 2015.
DOI: 10.1039/C4CC06951J

Behnam Azad B; Rota V; Yu L; St. Amant A; Lee TY; Dhanvantari S; Luyt LG. Synthesis and Evaluation of Optical and PET GLP-1 Peptide Analogues for GLP-1R Imaging. Molecular Imaging 14(2), 1-16, 2015.
DOI: 10.2310/7290.2014.00057

 

Hickey,JL; Simpson, ES; Hou, J; Luyt, LG. An Integrated Imaging Probe Design: The Synthesis of 99mTc/Re-Containing Macrocyclic Peptide Scaffolds. Chemistry – A European Journal 21(2), 568-578, 2015.
DOI: 10.1002/chem.201404774

Cruickshank, DR; Luyt, LG. The Development of Organometallic OBOC Peptide Libraries and Sequencing of N-Terminal Rhenium(I) Tricarbonyl-Containing Peptides Utilizing MALDI Tandem Mass Spectrometry. Can. J. Chem. 93(2), 234-243, 2015.
DOI: 10.1139/cjc-2014-0259

2014

 

Bruckman, M; Jiang, K; Simpson, E; Randolph, L; Luyt, L; Yu, X; Steinmetz, N. Dual-modal magnetic resonance and fluorescence imaging of atherosclerotic plaques in vivo using VCAM-1 targeted tobacco mosaic virus. Nano Letters 14(3), 1551-1558, 2014.
DOI: 10.1021/nl404816m

Douglas, GA; McGirr. R; Charlton, CL; Kagan, DB; Hoffman, LM; Luyt, LG; Dhanvantari, S. Characterization of a far-red analog of ghrelin for imaging GHS-R in P19-derived cardiomyocytes. Peptides, 54: 81-88, 2014.
DOI: 10.1016/j.peptides.2014.01.011

2013

 

Cho, CF; Behnam Azad, B; Luyt, LG; Lewis, JD. High-throughput screening of one-bead one-compound peptide libraries using intact cells. ACS Combi. Sci.  15(8), 393-400, 2013.

DOI: 10.1021/co4000584

2012

 

Cho, CF; Amadei, G; Breadner, D; Luyt, LG; Lewis, JD. The discovery of novel integrin ligands from combinatorial libraries using a multiplex ‘beads on a bead’ approach. Nano Lett., 12(11), 5957-5965, 2012.
DOI: 10.1021/nl3034043

Hickey, J.L.; Luyt, L.G. Synthesis of Rhenium-centric Reverse Turn Mimics. Chemistry – A European Journal, 18(41), 12999-13007, 2012.
DOI: 10.1002/chem.201201766

Tolg C; Zalinska E;  Hamilton S; McCulloch L;  Akentieva N; Winnik F; Savani R; Bagli D; Luyt LG; Amin, R; Cowman, MK; McCarthy, JB;  Turley EA. A RHAMM mimetic peptide blocks hyaluronan signaling and reduces inflammation and fibrogenesis in excisional skin wounds. Am. J. Pathology, 181(4): 1250–1270, 2012.
DOI: 10.1016/j.ajpath.2012.06.036

 

Simpson, EJ; Hickey, JL; Breadner, D; Luyt, LG. Investigation of Isomer Formation Upon Coordination of Bifunctional Histidine Analogues with 99mTc/Re(CO)3. Dalton Transactions 41(10), 2950-2958, 2012.
DOI:10.1039/C2DT11962E

Behnam Azad, B; Cho, F; Lewis, JD; Luyt, LG. Synthesis, Radiometal labeling and In Vitro Evaluation of a Targeted PPIX Derivative. Applied Radiation and Isotopes. 70(3), 505-511, 2012.
DOI:10.1016/j.apradiso.2011.11.054

Veiseh, M, Breadner, D; Akentieva, N; Savani, RC; Harrison, RE; Mikilus, D; Collis, L; Lee, T-Y; Koropatnick, J; Bissell, MJ; Luyt, LG; Turley, EA.  Hyaluronan-Based Imaging Probes Detect Injured and Neoplastic Tissues and their Microenvironments.  Biomacromolecules. 13(1), 12-22, 2012.
DOI: 10.1021/bm201143c

Lu, C; McFarland, MS; Williams, AK; Chan, S; Gomez-Lemus, J; Chin, J; Izawa, J; Luyt, LG; Lewis, JD. Ghrelin Receptor as a Novel Imaging Target for Prostatic Neoplasms. The Prostate, 72(8), 825-833, 2012.
DOI: 10.1002/pros.21484

 

Selected Articles 2011 and earlier

 

McTavish, J; McFarland, MS; Luyt, LG; Dhanvantari, S. Design and Characterization of a Fluorescent Ghrelin Analogue for Imaging the Growth Hormone Secretagogue Receptor 1a. Regulatory Peptides, 172, 69-76, 2011

DOI: 10.1016/j.regpep.2011.08.011.

 

 

Steinmetz, NF*; Ablack, A*; Hickey, JL*; Ablack, J; Mymryk, JS; Luyt, LG; Lewis, JD. Intravital imaging of human prostate cancer using bombesin-targeted viral nanoparticles.  Small, 7(12), 1664-1672, 2011

DOI: 10.1002/smll.201000435.

 

 

Toelg, C; Hamilton, SJ; Morningstar, L; Zhang, J; Esguerra, KVN; Telmer, P; Luyt, LG; Harrison, R; McCarthy, JB; Turley, E.  Rhamm promotes interphase microtubule instability and mitotic spindle integrity through Mek1/Erk1,2 activity.  J Biological Chemistry, 285, 26461-26474, 2010

doi: 10.1074/jbc.M110.121491

 

 

Behnam Azad, B.; Rota, V.; Breadner, D.; Dhanvantari, S.; Luyt, L.G.  Design, Synthesis and In Vitro Characterization of Glucagon-Like Peptide-1 Derivatives for Pancreatic Beta Cell Imaging by SPECT.  Bioorganic and Medicinal Chemistry, 18, 1265-1272, 2010.
DOI: 10.1016/j.bmc.2009.12.032

 

 

Amadei, G., Cho, C.F., Lewis, J.D., Luyt, L.G.  Fast, reproducible and low-cost method for sequence deconvolution of “on-bead” peptides via “on-target” MALDI-TOF/TOF spectrometry. J. Mass Spectrometry, 45(3), 241-251, 2009

DOI: 10.1002/jms.1708

 

 

Martin, A.L., Hickey, J.L., Ablack, A., Lewis, J.D., Luyt, L.G., Gillies, E.R.  Synthesis of bombesin-functionalized iron oxide nanoparticles and their specific uptake in prostate cancer cells.  J. Nanoparticle Research, 12(5), 1599-1608, 2010

doi:  10.1007/s11051-009-9681-3

 

 

Rosita, D.; DeWit, M.; Luyt, L.G.  Fluorine and rhenium substituted ghrelin analogues as potential imaging probes for the growth hormone secretagogue receptor.  J. Med. Chem., 52(8), 2196-2203, 2009.
DOI: 10.1021/jm8014519